The fire broke out about 5:40 a.m. on Maysel Laurel Ridge Road.

A child woke up and smelled smoke, then alerted the rest of the family.

Clay Volunteer Fire Department Chief Michael Scott said a family of nine lived in the home, all escaping the blaze.

Scott said two children had smoke inhalation and two adults had burns, all being taken to a regional hospital.

Scott said he believes a space heater initiated the fire after something fell on or leaned against it.

There were no fire alarms inside the home.