The former GE Plastics plant employs 220 employees in Wood County.
The company, now known as SABIC, has laid-off 80 workers.
The company says they will be looking first for employees who are willing to leave voluntarily.
The lay-offs will happen in April.
The former GE Plastics plant was purchased by SABIC in May 2007. GE bought the plant from Borg-Warner Chemicals in 1988.
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